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| Reis,Karinna Bannach; Côrtes,Marcio Vinicius de Carvalho Barros; Martins,Frederico Severino; Filippi,Marta Cristina Corsi de; Paula,José Realino de; Conceição,Edemilson Cardoso da. |
| Abstract: The objective of this work was to purify and standardize the rue (Ruta graveolens) extract and evaluate its effect on Magnaporthe oryzae as an alternative to the integrated management of rice blast. The drug was characterized, the liquid extract was obtained, and the methodology for quantifying the standard markers psoralen and bergapten was validated. Rue extract and the markers, solely or in combination, were assayed in vitro, as well as in greenhouse conditions, for their ability to suppress leaf blast, by the evaluation of mycelial growth, conidial germination, and appressorium formation. Rue extract inhibited M. oryzae mycelial growth (100%), conidial germination (LD50=0.237 mg), and the appressorium formation (LD50=0.121 mg); besides, the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Magnaporthe oryzae; Ruta graveolens; Bergapten; Psoralen. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-204X2015001201121 |
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| Cruz,Lavínia Almeida; Guecheva,Temenouga Nikolova; Bonato,Diego; Henriques,João Antônio Pêgas. |
| Eukaryotic cells have developed mechanisms to prevent genomic instability, such as DNA damage detection and repair, control of cell cycle progression and cell death induction. The bifunctional compound furocumarin 8-methoxy-psoralen (8-MOP) is widely used in the treatment of various inflammatory skin diseases. In this review, we summarize recent data about the role of chromatin remodeling in the repair of DNA damage induced by treatment with 8-methoxypsoralen plus UVA (8-MOP+UVA), focusing on repair proteins in budding yeast Saccharomyces cerevisiae, an established model system for studying DNA repair pathways. The interstrand crosslinks (ICL) formed by the 8-MOP+UVA treatment are detrimental lesions that can block transcription and replication, leading to... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: DNA repair; Psoralen; Chromatin remodeling; Histones; DNA interstrand cross-links. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000600021 |
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